Schumacher Lab Publications

Bayersdorf R, Schumacher B.
Recent advances in understanding the mechanisms determining longevity.
F1000Res. 2019 Aug 9;8. pii: Faculty Rev-1403. doi: 10.12688/f1000research. 19610.1. eCollection 2019.

Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B.
Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells
Dev Cell. 2019 Jul 22;50(2):167-183.e8. doi: 10.1016/j.devcel.2019.06.012.

Doll MA, Soltanmohammadi N, Schumacher B.
ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstreamof the Core Apoptotic Machinery in Caenorhabditis elegans.
Genetics. 2019 Jul 11. pii: genetics.302458.2019. doi: 10.1534/genetics.119.302458.

Williams AB, Heider F, Messling JE, Riekher M, Bloch W, Schumacher B.
Restorationof Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans.
Genetics. 2019 Jun 27. pii: genetics.302422.2019. doi: 10.1534/genetics.119302422. [Epub ahead of print]

Jachimowicz RD, Beleggia F, Isensee J, Bhavana VB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Pfeifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y.
UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.
Cell, 2019 Jan 24;176, 1-15. doi: 10.1016/j.cell.2018.11.024

Habermehl TL, Parkinson KC, Hubbard GB, Ikeno Y, Engelmeyer JI, Schumacher B, Mason JB.
Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.
Geroscience. 2018 Dec 13. doi: 10.1007/s11357-018-0049-4. [Epub ahead of print]

Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N.
Mitochondrial stress prevents C. elegans germline apoptosis via BRCA1/BARD1 tumor suppressor genes independently from its pro-longevity effect.
EMBO Rep. 2018, e45856. doi: 10.15252/embr.201845856. Epub 2018 Oct 26.

Torgovnick A#, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F, Vogel W, Klümper N, Nolte H, Wittersheim M, Tharun L, Castiglione R, Krüger M, Schauss A, Perner S, Pasparakis M, Büttner R, Persigehl T, Hucho T, Herter-Sprie GS, Schumacher B#, Reinhardt HC#.
The Cdkn1aSUPER mouse as a novel tool to study p53-mediated tumor suppression.
Cell Rep. 2018 Oct 23;25(4), 1027-1039. doi: 10.1016/j.celrep.2018.09.079
(#co-corresponding authors)

Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N.
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans.
Cell Rep. 2018 Oct 2;25(1):199-211.e6. doi: 10.1016/j.celrep.2018.09.009.